To support R&D work for the blending of DPI (dry-powder inhaler) formulations, Hosokawa Micron has developed the Mini Cyclomix lab mixer. Based on the proven Cyclomix high shear blending technology the Mini Cyclomix incorporates may key features that add real benefits for use in the development of pharmaceutical powders.
Blending formulations for dry-powder inhalers (DPIs) is a delicate matter. Delivering a fully homogeneous blend, without deterioration of the particles is a prerequisite. To disperse the actives in the lactose, the cohesive forces between the fine particles need to be broken, requiring a certain amount of mechanical energy. If too much energy is applied however, adhesive forces between the carrier and the actives will be too high, limiting the separation during inhalation. Finding the right balance for the required mixing energy is a critical issue and calls for a very efficient mixer.
Exchangeable product bowls
The unit is highly versatile with exchangeable product bowls of 100 ml, 1 ltr or 2 ltr. Easily connected to the drive unit by a bayonet ring without any special tools. It is also possible to extend the range of bowls in the future.
Offline filling and discharging
Because the product bowls are detachable, they can be filled and discharged in a separate location such as a dispensary or a glovebox. The bowl can be taken to the drive unit as a contained bowl.
Simple, efficient operation
Integrated touch panel operation and featuring straightforward recipe management, data logging and data export.
The large surface area, in relation to the product volume, makes the Cyclomix a very efficient mixer compared with other high shear blenders, resulting in a homogeneous blend with a minimum input of mechanical energy.
Suitable for mixing, coating, bonding, rounding or densification, making it a very versatile device.
For further information/reader enquiries, please contact:
Hosokawa Micron Ltd
We offer a single source supply for the very best in proven processing machinery with associated technical expertise across process technologies and industries to deliver individual processing solutions to meet specific needs.