The complexities involved in monitoring and controlling fermentation parameters across multiple benchtop bioreactors, can lead to costly batch failure. Incorrect analytical sensor readings can result in lower productivity and extended runs, additional downstream processing, and reduced product quality.
Most fermentation processes require strict sterility with in-line analytical sensors sterilised prior to inoculation, especially fermentation conducted in benchtop bioreactors autoclaved to obtain sterility prior to starting a batch.
Analytical sensors for monitoring pH and dissolved oxygen (and, if required, CO2) are fundamental for ensuring maximum batch yield in the optimal time.
Implementing pH and optical dissolved oxygen analytical sensors with METTLER TOLEDO’s Intelligent Sensor Management (ISM®) at the bench scale can minimise the risk of batch contamination and loss.
Using on-board microprocessors, pH sensors with ISM continuously monitor their own condition, using internal algorithms to generate diagnostic tools that deliver valuable information to bioreactor operators. ISM technology also provides:
- A Dynamic Lifetime Indicator (DLI) which uses past and present stress on a sensor to predict when it will need to be replaced.
- The CIP / SIP counter records every occasion a sensor has been exposed to SIP / autoclaving temperatures.
- METTLER TOLEDO’s iSense PC software can be used post-batch to show on the remaining lifetime of the sensor.
The applications for ISM go well beyond benchtop bioreactors, and the same ISM sensors and transmitters can be used throughout Research and Development, process development and production to provide seamless scalability, reduce training and simplify stock control.
Call 0116 234 5095
Email enquire.mtuk@mt.com
