CPi Biotech Utilises Low Shear, Low Pulsation Pumps From Watson-Marlow For Its Bioprocess Skids

CPi Biotech makes use of a range of peristaltic pumps from Watson-Marlow Fluid Technology Solutions (WMFTS) to ensure its skid platforms provide major multinational biopharmaceutical companies with the flexibility to manage multiple processes.

Based in Cork, Ireland, CPi manufactures advanced bioprocess skids for the biopharmaceutical sector. Since 2017, CPi has integrated WMFTS pumps into its solutions for pH adjustment, depth filtration, virus filtration, virus inactivation, media and buffer preparation, final filling skids and customised single-use skids.

From smaller OEM 300 series flip-top pumps to larger process pumps—530, 630 and 730 series, and Quantum 600—CPi trusts Watson-Marlow pumps due to their low shear and low pulsation capabilities. Also important for CPi is the precision accuracy, fine adjustment of the pump speed and ease of use with single-use tubing assemblies.

The 530, 630, 730 cased pumps and the Quantum provide flexibility for CPi’s customers to manage multiple processes and save time due to their high turndown ratio and multiple options for tube materials and sizes.

The low shear, low pulsation pumping of up to 33 litres per minute are important qualities of the pumps and a requirement for CPi. Low shear is important so that the pump doesn't damage the protein and low pulsation so there is no impact on the functionality and accuracy of the inline instrumentation on the skid.

Ease of use is also critical. The large display clearly shows the pump status and provides for intuitive navigation with pump parameters easily set allowing for automated operation through the site control software.

With their compact size, Watson-Marlow OEM pumps are used where space saving is required, for ease of integration on skids, with multi-pump head configuration also available.

Watson-Marlow’s experience and longevity in the industry provides CPi with a portfolio of products from a trusted source extending to gaskets, tubing and clamps being incorporated on its skids. Sales and technical support are also very important as CPi customises its products through collaboration.

CPi’s skid solutions save its customers real-time plant, process and molecule re-configuration time as well as enabling ongoing re-investment in bioprocessing skids. The Single Pass Tangential Flow Filtration (SPTFF) system from CPi, which features Watson-Marlow panel mount 300 series pumpheads, can be deployed in many downstream unit operations, including clarification, chromatography, and final ultrafiltration steps.

The SPTFF saves on cleanroom space and the compact footprint of the 530, 630 and OEM panel mount pumps (300 series) means the pumps fit comfortably on to the platforms in CPi’s systems. Furthermore, LoadSure® tube elements offer high pressure and longer tube life.

CPi’s modular, scalable and flexible systems are being used by its customers in the development and cGMP manufacturing of life-saving medicines and therapeutics.

Not only do Watson-Marlow pumps deliver accuracy of up to +/-0.5% to guarantee process stability and product quality, but closed fluid path pumping assures complete isolation from any source of contamination during transfer, filling and filtration applications.

The Quantum 600 pump is specifically designed for linear flow under pressures of up to 3 bar as required for tangential flow filtration (TFF), virus filtration (VF), and high-performance liquid chromatography (HPLC) applications. It enables higher downstream process yields throughout the pressure range, with a maximum flow of 20 L/min.

Martin O’Reilly, Senior Life Sciences Engineer at Watson-Marlow Ireland, said: “Watson-Marlow's wide portfolio of products allows us to address many of CPi’s application challenges through the integration of both OEM panel mount pumps and cased pumps in their skid platforms.

“In relation to the Quantum, its unique single-use cartridge with four parallel fluid paths acts to deliver extremely low pulsation of only 0.12 bar at full speed, which is a key requirement for the reliable operation of many filtration processes. It is also easy to operate with colour display and intuitive menu structures which provide visual status indication and minimal key presses. This allows the user to adjust the speed gradually, and display relevant pump status information.”

Further information can be found at www.wmfts.com or www.cpibiotech.com.

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Watson-Marlow Fluid Technology Solutions

• 01326370370
• info@wmftg.co.uk
• https://www.wmfts.com/
• Bicklandwater Road, Falmouth Business Park, Falmouth, Cornwall, TR11 4RU GB
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About us

Watson-Marlow Fluid Technology Group (WMFTG) peristaltic tube and hose pumps meet requirements including: value for money; low cost of ownership; reliability and ease of maintenance to the food and beverage, chemical, pharmaceutical, mining and many other industries.

We demonstrate how pumps deliver significant process efficiencies over the lifetime of the equipment. Whether performing flavouring addition in food processing, chemical metering in water treatment or mineral recovery, we have a solution which can cut pump downtime and reduce costs through higher accuracy metering and transfer. WMFTG has dedicated application engineers available to help customers make the right pump and tubing choice from a range providing microlitres per minute to 80 cubic metres per hour flow rates.

The only part of the pump to come into contact with the product is the tube or hose. This means there are no seals or valves that can wear or fail. Replacing the tube or hose can be performed quickly and safely. Peristaltic pump benefits include:

Total fluid containment with no seals No ancillaries Handle viscous and abrasive slurries and sludge Self-priming capability Dry running without damage to the pump In addition to their range of positive displacement pumps, Watson-Marlow Fluid Technology Group has added PTFE-lined chemical and industrial hoses to their range. Aflex hoses are reinforced to withstand the most severe conditions and use.

Where we supply to

Europe, Africa, Asia, Australia, South America, North America

Industries we supply to

Automation, Chemicals, Consultants, Components Electronics, Energy and Power, Food and Beverage, Glass Ceramics Cement, Metals and Minerals, OEM, Paper and Pulp, Pharmaceutical Cosmetics Toiletries, Plastics and Rubber, Recycling, Textiles, Tobacco, Water and Wastewater

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